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By Ludwig M. Auer

This monograph goals to supply a survey of contemporary examine at the pathogenesis of hypertensive encephalopathy. Or, in different phrases, to narrate experimental effects on to a scientific challenge. i'm confident extremely important activity of experimental scientific learn is to discover purposes to the suitable medical challenge once attainable, and to prevent distraction through an more and more over­ whelming accumulation of latest details from all fields of clinical paintings. this can be definitely more straightforward for a clinician than for a scientist who's basically fascinated by primary learn; good fortune­ ful examine for scientific medication therefore calls for that clinicians and medical experts within the theoretical clinical branches cooperate with one another. to satisfy this goal the clinician has to be in a position to imagine in pathophysiological phrases to a substantial quantity, as a way to scarcely be attainable if he's occupied with regimen scientific medication by myself. Experimental paintings hence provides a true problem to the health professional who needs to resolve a scientific challenge and in addition possesses medical interest. along with a solution to his query, he has the chance to procure a true feeling for what he has realized to name "physiologi­ cal". i'm hoping with my very own experimental paintings to supply a powerful instance of ways such paintings might function a magnificent reminder to the clinician of the potentially grave outcomes of underestimating a improvement during a significant affliction, for example a hyper­ tensive episode following head injury.

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6. The Sausage-String Phenomenon Results for the estimation of sausages were obtained from animals of group 1 and the slow-increase experiments of group 2. Bloodpressure changes may be seen there. The sausage-string phenomenon was seen in eight out of ten normocapnic cats with neutral blood pH. Arterial diameter changes varied widely without a clear correlation between blood-pressure peak and the extent of vascular changes 17. Initial diffuse constriction with subsequent diffuse dilatation or segmental dilatation (sausages) was seen, as well as initial diffuse dilatation and subsequent constriction, often followed by formation of some sausages.

This state of maximal distension continued for more than 5 minutes (Fig. 19) in those two cats and then the state changed to one of segmental dilatation after 2 minutes in one cat (Fig. 20), a state which remained for more than 10 min% 800 600 400 200 ,. , :! 100 200 JIm Fig. 21. Arterial resting diameters of group 2 plotted against percentage diameter increase during hypertension. The curvilinear relationship is readily apparent utes. 94 ftm. 19 on average. 4 ~lm). 4%, which is twice normal. Individual results are given in Table 7.

5 10 10 10 10 10 30 30 20 20 15 15 30 15 10 25 100 95 100 45 35 40 40 65 100 100 45 95 100 90 60 45 50 35 30 100 95 65 55 70 20 75 35 35 35 135 140 135 80 85 70 75 130 0/0 Resting Peak didiameter ameter ~lm Exp. 2. Pial Arteriolar Diameter Changes During Hypertension 41 tion and constriction could be seen in one cat together with venous dilatation, similar to the results in group 1. In five animals, however, with a pressure increase of more than 80 0/0 (Table 6 B), diffuse arteriolar dilatation was found and, on average, was maximal after 30 seconds (Fig.

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