Posted in Cancer

Download Platinum and Other Metal Coordination Compounds in Cancer by Stephen J. Lippard (auth.), Stephen B. Howell (eds.) PDF

By Stephen J. Lippard (auth.), Stephen B. Howell (eds.)

Taken jointly the information provided during this evaluate, and paintings via many different investigators, aid the inspiration that DNA excision fix is necessary in a tumor cell's resistance to platinum compounds. Inhibition of this fix approach through blend chemotherapy with the excision fix inhibitors HU and Ara-C produces synergistic mobile kills and elevated degrees and persistance of DNA interstrand crosslinks. The reports with cis-DDP and ~-DDP together with UVĀ­ prompted thymine dimers recommend that there's festival for DNA fix enzymes among the dimer and the platinum lesion. no matter if the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of those lesions) can't be made up our minds. The similarity among an intrastrand crosslink and a cyclobutane dimer means that those lesions could compete for fix. in spite of the fact that, the elevated top degrees of interstrand crosslinks, and elevated endurance of those lesions at later time issues recommend that this lesion can also be a substrate for the fix method. those observations might be of medical relevance. lately Dr. Kathy Albain of our establishment has accomplished a part III I research utilizing a 12 hour pretreatment with HU and Ara-C in sufferers sooner than their cis-DDP treatment. She saw an important variety of responders during this trial (54). She is at the moment finishing a moment part IIII examine substituting IV HU for the oral formula. We count on starting up different medical trials established upon those observations.

Show description

Read Online or Download Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy PDF

Best cancer books

DNA Topoisomerases in Cancer Therapy: Present and Future

Within the mid 80's kind I and II enzymes have been stumbled on to be the intracellular ambitions of a few efficacious anticancer medications resembling doxorubicin, mitoxantrone, etoposide and camptothecin due to a persisted efforts of many investigators, specifically Leroy Liu and his collaborators at Johns Hopkins college.

Cancer Chemoprevention: Promising Cancer Chemopreventive Agents

A lot growth has been made in gaining knowledge of and constructing brokers that experience promise, or have already been effectively used, to regard precancerous stipulations or inhibit carcinogenesis. In melanoma Chemoprevention, quantity 1: Promising melanoma Chemopreventive brokers, prime researchers within the discovery and improvement of chemopreventives comprehensively survey all elements of those rising therapeutics.

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Taken jointly the information awarded during this assessment, and paintings by means of many different investigators, help the idea that DNA excision fix is critical in a tumor cell's resistance to platinum compounds. Inhibition of this fix method via mix chemotherapy with the excision fix inhibitors HU and Ara-C produces synergistic phone kills and elevated degrees and persistance of DNA interstrand crosslinks.

Cancer and Zebrafish: Mechanisms, Techniques, and Models

This quantity specializes in defining the original attributes of utilizing the zebrafish melanoma version for locating vital pathways and strength drug goals for the therapy of human cancers. utilizing the zebrafish version, the quantity explores oncogene and tumor suppressor discovery, chemical genetic techniques, genomics, epigenetics, melanoma imaging, and cellphone transplantation.

Additional resources for Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Sample text

Some prospectives for future studies in this problem area, as seen from an inorganic chemistry point of view, are: * Detailed kinetic studies to determine the rate-limiting step in the binding of Pt to S. This will be important in understanding the mechanisms of inactivation and resistance in normal tissues and tumors. * Systematic binding studies of a variety of Pt compounds with sulfurcontaining molecules, which would eventually lead to the development of new antitumor drugs with structural properties such that the ratio of Pt binding at DNA, compared to that of RSR', is increased.

At the outset in our conditions, there is a large excess of the dichloro species (25 per base pair). Therefore there is first a latence period during which the monoaquated intermediate starts to accumulate. Because of the excess of the dichloro species at the begining and because the two rates of aquation kl and k4 have similar values 5, the monoaquated intermediate will predominate for quite a long time before the diaqua species accumulates and becomes the main platinum reactant. In addition the second order rate of platination by the monoaquated intermediate, k2, is large enough to cause the rapid formation of the DNA monoadducts 5 The chelation step is expected to occur rather slowly.

K. Mascharak, I. D. Williams and S. J. Lippard, Characterization of a Platinum Pyrimidine Blue: Synthesis, Structure and Physical Properties of cis-Diammineplatinum I-Methyluracil Blue, J. Am. Chem. Soc. 106:6428 (1984). J. K. Barton, H. N. Rabinowitz, D. J. Szalda and S. J. Lippard, Synthesis and Crystal Structure of cis-Diamminplatinum a-Pyridone Blue, J. Am. Chem. Soc. 0 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 34 44. 45. 46. 47. 48. 49. 50. 51. 52. T. V. 0' Halloran, M. M. Roberts and S.

Download PDF sample

Rated 4.96 of 5 – based on 44 votes