By A. V. Schally (auth.), Eugenio E. Müller (eds.)
The booklet describes the facility of a chain of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert an instantaneous anti-neoplastic job or to potentiate the task of conventional chemotherapeutic brokers on neuroendocrine and reliable tumors. moreover, a brand new category of powerful GH-releasers, GSHs/Ghrelin, endowed with vital endocrine and extra-endcocrine motion, is gifted. consequently, as well as conventional chemotherapy, characterised by way of excessive toxicity and non-selective motion on tumoral cells, the reader can discover a new method with extra selective, much less cytotoxic endocrine derived compounds
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Extra resources for Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance: From Basic to Clinical Research
Clinical trials with cetrorelix in patients with advanced renal cell carcinoma are in progress in New Orleans. , Hayakawa M. and Nakamura H. (1996). Gene expression of TGF-a, EGF and IL-6 in cultured renal tubular cells and renal cell carcinoma. Int J Urol, 3, 392-396. Barry M. and Roehrborn C. (1997). Management of benign prostatic hyperplasia. Annu Rev Med, 48, 177-189. , Shapiro E. K. (1995). Regional concentration of basic fibroblast growth factor in normal and benign hyperplastic human prostates.
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3% vs. , 2000). 1 vs. , 2001). Larger randomized trials are needed to clarify the situation. LHRH Antagonists for Treatment of Uterine Fibroids Uterine fibroids represent the most common solid pelvic tumors and are associated with abnormal uterine bleeding and infertility. , 1985). Myomas are estrogen-dependent and rarely arise before puberty. Their progression stops after menopause. , 1995). , 1987), these compounds are mostly used to faciliate surgery by shrinkage of the fibroids if a uterus-conserving operation or vaginal hysterectomy is desired.