By Marek Jankowski, Tomasz Wandtke, Marta Jakubowska
This quantity makes a speciality of a variety of elements of interleukin-27 (IL-27), specifically its power for scientific functions. The authors talk about the downstream signaling from the IL-27 receptor and its molecular pursuits in immune cells together with Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells through IL-27 is essential for the upkeep of the feto-maternal tolerance and the prevention of lupus, a number of sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. even if, an analogous inhibitory functions compromise the immune reaction to bacterial pathogens, and IL-27 is a pathogenic consider sepsis and tuberculosis. additionally lined are the conflicting experiences at the function of IL-27 in rheumatoid arthritis, the impact of IL-27 on epithelia, which turns out to play a task in bronchial asthma, psoriasis and inflammatory bowel ailments, and the direct cytotoxic and anti-vascular results of IL-27, which make it a promising agent for the therapy of melanoma. for that reason, this quantity can be of curiosity to researchers and clinicians alike.
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This quantity specializes in quite a few elements of interleukin-27 (IL-27), particularly its power for scientific purposes. The authors speak about the downstream signaling from the IL-27 receptor and its molecular pursuits in immune cells together with Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells through IL-27 is key for the upkeep of the feto-maternal tolerance and the prevention of lupus, a number of sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis.
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Extra info for Interleukin-27: Biological Properties and Clinical Application
050013 Salcedo R, Stauffer JK, Lincoln E, Back TC, Hixon JA, Hahn C, Shafer-Weaver K, Malyguine A, Kastelein R, Wigginton JM (2004) IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells. J Immunol 173 (12):7170–7182 44 2 IL-27: A Key Player in Immune Regulation Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H (2014) IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.
2007; Ouaked et al. 2009; Peters et al. 2015); hence, other STAT1- or STAT3-activating cytokines may modulate the net effect of IL-27 stimulation. Contrary to the majority of data, Dong et al. (2016) reported inhibition of STAT1, STAT3, and STAT5 upon IL-27 stimulation in alveolar epithelial cells. Possible explanation to this discrepancy is differential baseline expression and/or capacity to upregulate SOCS3. IL-27 can also signal in a JAK/STAT-independent manner via the p38 and ERK1/2 MAPK as well as PI3K/Akt/mTOR signaling pathways (Diegelmann et al.
Who found that, in human T cells, IL-27 substantially enhances TGF-b-induced Foxp3 expression. Increased numbers of Foxp3+ Treg cells have been later shown in IL-27 mice in collagen-induced arthritis model (Ouaked et al. 2009; Moon et al. 2013); conversely, a striking deﬁciency in Treg numbers has been observed in GALT of IL-27−/− mice (Hall et al. 2012). This dual effect on FoxP3 expression and Treg differentiation could possibly be explained by concomitant activation of STAT1 and STAT3 by IL-27.