By M. Åkerman, H.A. Domanski, K. Jonsson, P. Vielh
In recent times, fine-needle aspiration cytology (FNAC) has turn into a commonly permitted technique within the prognosis of bone lesions. swift development in immunocytochemistry and molecular genetics has elevated the function of FNAC within the research of basic bone lesions. the aim of this ebook is to facilitate the cytological assessment of FNA smears from skeletal lesions and to supply diagnostic standards in response to the mixed review of scientific info and radiographic and cytological gains. the main target is to entirely describe and illustrate the commonest entities in addition to the diagnostic use of ancillary innovations. a few infrequent basic bone tumours/lesions also are illustrated.The number of entities illustrated during this complete guide relies frequently on event with sufferers talked about the Musculoskeletal Centre in Lund, Sweden, which now contains smear facts from nearly one thousand skeletal tumours/lesions accumulated among 1966 and 2006.This e-book can be a beneficial source for pathologists, cytopathologists, radiologists, oncologists and orthopaedic surgeons fascinated about the work-up and administration of sufferers with bone lesions.
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Extra info for Fine Needle Aspiration of Bone Tumours: The Clinical, Radiological, Cytological Approach (Monographs in Clinical Cytology Vol 19)
Cells are in lacunae within fragments and single cells are very uncommon. The chondrocytes appear small and uniform. Chondromas of the hands and feet may be cellular and show more or less marked anisokaryosis and binucleation. Differential Diagnosis The differential diagnosis is low-grade malignant chondrosarcoma Comments Combined evaluation of radiological and cytological features is mandatory in order to avoid a false-positive diagnosis of low-grade malignant chondrosarcoma. This is especially important in tumours of the hands and feet.
Histopathology Chondromas are rather paucicellular tumours with abundant hyaline cartilaginous matrix. The chondrocytes are present within lacunae, have small nuclei and sometimes small nucleoli. The chondrocytes can be arranged in small clusters or are evenly distributed. Binucleated chondrocytes may occur. Typically, chondromas of the hands and feet are more cellular and may exhibit cellular pleomorphism with relatively marked anisokaryosis. Cytological Features See figure 27. There are cartilaginous tissue fragments, which appear red-purple in MGG and DiffQuick and pale, faintly pink, in wet-fixed smears.
D Compared to low-grade chondrosarcoma there is marked cellular and nuclear atypia. HE, medium magnification. cellular and nuclear pleomorphism with prominent nucleoli and occasional mitosis. Differential Diagnosis The differential diangnoses are: chondroma; chondroblastic osteosarcoma; chordoma, and metastastatic adenocarcinoma. Comments Most primary chondrosarcomas are easy to needle and the yield is often surprisingly high. Chondrosarcoma with reactive periosteal bone formation and heavily calcified tumours 38 are exceptions.