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Download DNA Topoisomerases in Cancer Therapy: Present and Future by James C. Wang (auth.), Toshiwo Andoh (eds.) PDF

By James C. Wang (auth.), Toshiwo Andoh (eds.)

In the mid 80's variety I and II enzymes have been came upon to be the intracellular ambitions of a couple of efficacious anticancer medicines reminiscent of doxorubicin, mitoxantrone, etoposide and camptothecin because of a persisted efforts of many investigators, specifically Leroy Liu and his collaborators at Johns Hopkins collage. Readers will discover a sequence of chapters written by way of researchers actively engaged within the increasing box of topoisomerase and their inhibitors. The sequence of chapters hide overview articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer medicinal drugs in mammals and within the yeast Saccharomyces cerevisiae, which has proved to be an exceptional version organism for stories of anticancer medicines. This quantity compiles up to date info at the topoisomerase-targeting compounds in medical and preclinical improvement as an invaluable and demanding reference publication for college kids and researchers within the box of pharmacology, toxicology, oncology and molecular biology.

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