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Download Diabetic Neuropathy: Clinical Management (Clinical Diabetes) by Aristides Veves, Rayaz A. Malik PDF

By Aristides Veves, Rayaz A. Malik

During this up-to-date version, top clinical experts severely assessment for the overall practitioner the newest ideas for the scientific administration of diabetic neuropathy. The members concentrate on the sensible elements of diabetic neuropathy and describe intimately the remedies which are at present to be had or anticipated to turn into on hand within the close to destiny. additionally they contain concise discussions of the pathogenesis of diabetic neuropathy.

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Extra info for Diabetic Neuropathy: Clinical Management (Clinical Diabetes)

Example text

Case–control studies have addressed whether diabetes is a significant risk factor for CTS. In the earliest study, 156 cases were identified from the population by selfreport (n = 28) and from neurology clinic (n = 128), and controls were 476 subjects without CTS from the community (44). The diagnosis of CTS was confirmed by neurophysiological testing. 8). In order to examine the effect of selection bias, risk factor analysis was repeated for the 28 cases derived from the population (rather than clinic) and yielded similar results.

From: Contemporary Diabetes: Diabetic Neuropathy: Clinical Management, Second Edition Edited by: A. Veves and R. , Totowa, NJ 31 32 Demaine and Yang Fig. 1. Hyperglycemia-induced metabolic abnormalities because of increased flux through the polyol pathway. GENETIC FACTORS AND DIABETIC NEUROPATHY Over the past few years considerable data have emerged showing that genetic factors make an important contribution to the pathogenesis of diabetic microvascular complications (15). This explains why certain patients with good glucose control still develop diabetic microvascular complications, whereas, there are those with poor control who appear to escape the long-term complications of diabetes.

Franklin GM, Shetterly SM, Cohen JA, Baxter J, Hamman RF. Risk factors for distal symmetric neuorpathy in NIDDM. Diabetes Care 1994;17:1172–1177. 6. Maser RE, Steenkiste AR, Dorman JS, et al. Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456–1461. 7. Maser RE, NielsenVK, Bass EB, et al. Measuring diabetic neuropathy. Assesssment and comparison of clincial examination and quantitative sensory testing. Diabetes Care 1989;12:270–275.

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