By Marçal Pastor-Anglada MSc, PhD (auth.), Godefridus J. Peters PhD (eds.)
Emerging as a major new quantity within the popular melanoma Drug Discovery and improvement™ sequence, Deoxynucleoside Analogs in melanoma treatment expertly summarizes the present prestige of improvement and alertness of deoxynucleoside analogs. Authoritative up to date reports are awarded through scientists renowned of their particular components and all contributions comprise worthwhile sound suggestion on constitution and topics.
equipped into numerous sections, the 1st half covers common elements of drug uptake and metabolism and explains how novel know-how has enabled a speedy enlargement of this box. the second one half is anxious with a couple of particular medicines together with cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. the ultimate part covers pharmacokinetics, prodrugs, and particular functions resembling radiosensitization, gene remedy, and using deoxynucleoside analogs as tracers.
all through Deoxynucleoside Analogs in melanoma treatment, the focal point is on novel elements of deoxynucleoside analogs within the medical context, in addition to on unforeseen goals of those compounds, akin to their particular task opposed to mobilephone cycle-dependent kinases or oncogenes. The wealth of data awarded right here can be utilized to layout rational mixtures geared toward inhibiting a variety of mobile signaling pathways, or combining inhibition of varied goals. Deoxynucleoside Analogs in melanoma treatment has been designed particularly to facilitate such an interplay among a variety of fields.
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Additional resources for Deoxynucleoside Analogs In Cancer Therapy
DCK is the only enzyme that can supply cells with all four precursors of DNA. The final product of the salvage, beside of DNA (8–10), the deoxycytidine triphosphate (dCTP) can also be utilized for special processes, for synthesis of “liponucleotides,” precursors of membrane phospholipids (11–14). Treatments of patients with dCyt analogs often resulted in neuropathy as a side effect, which might be the result of altered phospholipid biosynthesis. dCyt is incorporated into dCDP-ethanolamine and dCDPcholine more effectively than cytidine itself, and the anticancer analog arabinosyl-cytosine also participates in these reactions (11–13).
There was overall a good correlation between these three parameters, except in some cases. These results may be important for future studies in which the level of dCK in patients could be considered as a parameter to obtain individualized chemotherapy with nucleoside analogs, potentially leading to higher efficacy and reduced side effects. A positive correlation was found between dCK activity and the sensitivity of malignant cells to chemotherapy (20–23), discussed in Section 7. , point mutations, exon deletions, and alternatively spliced mRNAs).
Huang QQ, Yao SY, Ritzel MW, Pateron AR, Cass CE, Young JD. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J Biol Chem 1994;269:17,757–17,760. 4. Che M, Ortiz DF, Arias IM. Primary structure and functional expression of a cDNA encoding the bile canalicular purine-specific Na+-nucleoside cotransporter. J Biol Chem 1995;270:13,596–13,599. 5. Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).