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Download Clinical Use of Calcium Channel Antagonist Drugs by Lionel H. Opie MD, PhD, FRCP, William A. Coetzee DSc (auth.) PDF

By Lionel H. Opie MD, PhD, FRCP, William A. Coetzee DSc (auth.)

Calcium antagonists are actually considered as crucial develop in cardiac drug treatment because the introduction of beta-adrenergic blockading brokers. appearing ba­ sically as vasodilators-though with many different com­ plex mechanisms specially with regards to the anti­ arrhythmic calcium antagonists, those brokers have grown in value to develop into one of the healing brokers of first selection for angina pectoris and hyper­ stress. the main target of the current publication is to provide the clinician with the knowledge wanted for the sensible use of calcium antagonists. What do the entire quite a few and infrequently conflicting trials say? Do those brokers rather paintings? if this is the case, which agent and in what dose? How do the 3 entrance runners, verapamil, nifedipine and diltia­ zem examine within the efficacy and side-effects with one another? How do the hot moment new release brokers, now getting into the North American marketplace, fit in and com­ pare with the 3 first-liners? while the gloss is taken clear of the ads, what's rather left? The powerful scientific bias of the current booklet may be complimented by means of additional examining of books slanted in the direction of basics. probably the most vital and up to date of those is that through Dr Winifred Nayler (Calcium Antagonists, educational Press, 1988). That publication will be uncomplicated for crucial history wisdom within the sector of calcium antagonists. the real uncomplicated contribu­ tions of Fleckenstein deserve emphasis.

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Extra resources for Clinical Use of Calcium Channel Antagonist Drugs

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75. Carmeliet E, Ramon J: Effect of acetylcholine on timedependent currents in sheep cardiac Purkinje fibers. ptlugers Arch 1980;387:217-223. 76. CarmeJiet E, Mubagwa K. Changes by acetylcholine of membrane currents in rabbit cardiac Purkinje fibers. J PhysioI1986;371:201-217. 77. Fishmeister R, Hertzell HC. Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle. J PhysioI1986;376:183-202. 78. Mubagwa K, Carmeliet E. Electrophysiological effects of acetylcholine on rabbit cardiac Purkinje fibers.

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J PhysioI1984;349:48P. Cavalie A, Pelzer D, Trautwein W. Fast and slow gating behavior of Ringle calcium channels in cardiac cells. Rela· tion to activation and inactivation of calcium·channel current. Pflugers Arch 1986;406:241-258 Opie LH. Effects of regional ischemia on metabolism of glucosc, and fatty acids. Relative rates of aerobic and anaerobic energy production during myocaridal infarction and comparison with effects of anoxia. ' 1976; 38:(Supplll:lfi2-74. Hearse D,r, Garlick PB, Humphrey SM.

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