Posted in Clinical

Download Clinical Use of Antiviral Drugs by B. E. Juel-Jensen (auth.), Professor Dr. Erik De Clercq PDF

By B. E. Juel-Jensen (auth.), Professor Dr. Erik De Clercq (eds.)

Antiviral chemotherapy has come of age, and, after an preliminary sluggish seasoned­ gress, the advance of recent antiviral brokers has proceeded at a extra fast speed and the views for his or her medical use have elevated significantly. Now, 25 years after the 1st antiviral assay (idoxuridine) was once brought within the health center, it really is becoming to commemorate the start of the antivirals' period. In its introductory bankruptcy B.E. Juel-Jensen touches on what will be con­ sidered as 5 of the main basic necessities of an antiviral drug : efficacy, relative non-toxicity, effortless solubility, prepared availability and rea­ sonable expense. absolutely, the antiviral medicines that experience to this point been utilized in the medical institution may possibly nonetheless be better upon as a number of of those 5 crucial calls for are involved. How is all started is narrated via W.H. Prusoff. the 1st antiviral medications for use in people have been methisazone and idoxuridine, the previous, that is now of archival curiosity, within the prevention of smallpox, the latter, which was once authorized for scientific use within the usa in 1962, for the topical remedy of herpetic keratitis. when it comes to efficiency, additionally due to solubility purposes, idoxuridine has been outmoded through trifluridine within the topical therapy of herpes simplex epithelial keratitis. H.E. Kaufman didn't locate trifluridine or acyclovir ef­ fective within the remedy of deep stromal keratitis or iritis and he reckons that different antiviral medicinal drugs (i.e. bromovinyldeoxyuridine) wouldn't be effec­ tive either.

Show description

Read or Download Clinical Use of Antiviral Drugs PDF

Similar clinical books

The Pathogenesis of Hypertensive Encephalopathy: Experimental Data and Their Clinical Relevance With Special Reference to Neurosurgical Patients

This monograph goals to supply a survey of contemporary learn at the pathogenesis of hypertensive encephalopathy. Or, in different phrases, to narrate experimental effects on to a scientific challenge. i'm confident vitally important job of experimental scientific study is to discover functions to the correct medical challenge once attainable, and to prevent distraction through an more and more over­ whelming accumulation of recent info from all fields of medical paintings.

Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance: From Basic to Clinical Research

The publication describes the facility of a chain of endocrine-derived compounds, i. e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert an immediate anti-neoplastic job or to potentiate the job of conventional chemotherapeutic brokers on neuroendocrine and sturdy tumors. additionally, a brand new classification of powerful GH-releasers, GSHs/Ghrelin, endowed with vital endocrine and extra-endcocrine motion, is gifted.

Lifelines: Clinical Perspectives on Suicide

Suicide is a resource of never-ending disquiet. one of many few deadly outcomes of psychiatric sickness, it's a chance to sufferers, and a vexation to therapists that places medical judgment to the final word try. It arouses countertransference reactions of bizarre intensity-helplessness and guilt while the suicide is winning; anxiousness and anger whilst it truly is used as a manipulative device.

Interleukin-27: Biological Properties and Clinical Application

This quantity makes a speciality of quite a few facets of interleukin-27 (IL-27), specifically its capability for medical functions. The authors talk about the downstream signaling from the IL-27 receptor and its molecular ambitions in immune cells together with Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells via IL-27 is essential for the upkeep of the feto-maternal tolerance and the prevention of lupus, a number of sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis.

Additional info for Clinical Use of Antiviral Drugs

Example text

Chern. 1: 305-318, 1905-06. A. B. Science 102: 251-252, 1945. B. D. Biochem. J. 67: 494-506, 1957. , Zamenhof, S. and Griboff, G. Nature 174: 305307, 1954. Luzzati, D. Compt. Rend. Acad. Sci. 245: 1466-1468, 1957. - 24 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. eo. Bl. 82. 83. 84. Zamenhof, S. and Griboff, G. Nature 174: 307-308, 1954. L. D. Cancer Res. 13: 221-225, 1953. A. ana Schoenheimer, R. J. Eiol. Chem. 153: 203-217, 1944.

Sr. J. Ophthalmol. 69:847-850, 1985. 34. C. MAUDGAL 11: and E. 1 % brOlllovinyldeoxyuridine (BVDU) eyedrops. e. idoxuridine, vid~rabine, trifluridine and/or Zovirax, till the time their treatment W&b swit- ched to BVDU. 6 days upon BVDU therapy. Similarly, 35 patients with geographic corneal ulcers healed within an average time of 11. 7 days, and 42 patients with stromal keratitis healed within au average time of 30 days upon BVDU therapy. s to BVDU eyedrops in a small number of patients, no other local or systemic toxic effects were observed.

Chastel. E. and Kissling, G. In preparation. 44. Collum. • Patterson, A. J. Sr. J. Ophthalmol. 69:847-850, 1985. 34. C. MAUDGAL 11: and E. 1 % brOlllovinyldeoxyuridine (BVDU) eyedrops. e. idoxuridine, vid~rabine, trifluridine and/or Zovirax, till the time their treatment W&b swit- ched to BVDU. 6 days upon BVDU therapy. Similarly, 35 patients with geographic corneal ulcers healed within an average time of 11. 7 days, and 42 patients with stromal keratitis healed within au average time of 30 days upon BVDU therapy.

Download PDF sample

Rated 4.88 of 5 – based on 26 votes