By B. E. Juel-Jensen (auth.), Professor Dr. Erik De Clercq (eds.)
Antiviral chemotherapy has come of age, and, after an preliminary sluggish seasoned gress, the advance of recent antiviral brokers has proceeded at a extra fast speed and the views for his or her medical use have elevated significantly. Now, 25 years after the 1st antiviral assay (idoxuridine) was once brought within the health center, it really is becoming to commemorate the start of the antivirals' period. In its introductory bankruptcy B.E. Juel-Jensen touches on what will be con sidered as 5 of the main basic necessities of an antiviral drug : efficacy, relative non-toxicity, effortless solubility, prepared availability and rea sonable expense. absolutely, the antiviral medicines that experience to this point been utilized in the medical institution may possibly nonetheless be better upon as a number of of those 5 crucial calls for are involved. How is all started is narrated via W.H. Prusoff. the 1st antiviral medications for use in people have been methisazone and idoxuridine, the previous, that is now of archival curiosity, within the prevention of smallpox, the latter, which was once authorized for scientific use within the usa in 1962, for the topical remedy of herpetic keratitis. when it comes to efficiency, additionally due to solubility purposes, idoxuridine has been outmoded through trifluridine within the topical therapy of herpes simplex epithelial keratitis. H.E. Kaufman didn't locate trifluridine or acyclovir ef fective within the remedy of deep stromal keratitis or iritis and he reckons that different antiviral medicinal drugs (i.e. bromovinyldeoxyuridine) wouldn't be effec tive either.
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Sr. J. Ophthalmol. 69:847-850, 1985. 34. C. MAUDGAL 11: and E. 1 % brOlllovinyldeoxyuridine (BVDU) eyedrops. e. idoxuridine, vid~rabine, trifluridine and/or Zovirax, till the time their treatment W&b swit- ched to BVDU. 6 days upon BVDU therapy. Similarly, 35 patients with geographic corneal ulcers healed within an average time of 11. 7 days, and 42 patients with stromal keratitis healed within au average time of 30 days upon BVDU therapy. s to BVDU eyedrops in a small number of patients, no other local or systemic toxic effects were observed.
Chastel. E. and Kissling, G. In preparation. 44. Collum. • Patterson, A. J. Sr. J. Ophthalmol. 69:847-850, 1985. 34. C. MAUDGAL 11: and E. 1 % brOlllovinyldeoxyuridine (BVDU) eyedrops. e. idoxuridine, vid~rabine, trifluridine and/or Zovirax, till the time their treatment W&b swit- ched to BVDU. 6 days upon BVDU therapy. Similarly, 35 patients with geographic corneal ulcers healed within an average time of 11. 7 days, and 42 patients with stromal keratitis healed within au average time of 30 days upon BVDU therapy.