By Joseph Wybran, Maurice J. Staquet
Medical Tumor Immunology comprises the court cases of the Symposium of scientific Tumor Immunology held in Brussels, Belgium, on may well 26-29, 1975) and arranged via the eu association for examine on remedy of melanoma in cooperation with the dept of Immunology of the collage medical institution of Brussels. The papers discover growth within the box of medical tumor immunology and canopy subject matters starting from common mechanisms in tumor immunity to tumor antigens and immunotherapy. A type of leukemias and lymphomas can be presented.
Comprised of forty eight chapters, this publication starts off with an summary of the organic actions of the circulating thymic hormone, via a dialogue on macrophage secretions affecting the expansion of alternative cells. The reader is then brought to immune mobile mechanisms on the website of the tumor; using the leukocyte migration method in stories of tumor-directed mobile immunity in malignant cancer; and immunological methods to the identity of leukemic cells. next chapters take care of preclinical methods in tumor immunochemotherapy; mediation of immune responses to human tumor antigens with "immune" RNA; and the position of move consider human cancer.
This monograph might be of curiosity to oncologists and immunologists.
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Extra info for Clinical Tumor Immunology
T. BRUNNER Department of Immunology, Swiss Institute Lausanne Unit of Human Cancer Immunology, in conjunction with Policlinique Mtdicale for Experimental Cancer Research and Ludwig Institute for Cancer Research, Universitaire, Lausanne, Switzerland INTRODUCTION During the last 5 years, several authors have reported the occurrence, in blood of cancer patients, of leukocytes which exerted a toxic effect in vitro on cultured syngeneic or allogeneic tumor cells (for references, see Hellstrom and Hellstrom ).
In addition to CTL, C E L L - M E D I A T E D C Y T O T O X I C I T Y IN M 45 VITRO Table 2. 51 Cytolytic Activity of PBL from Normal Individuals on Cr Labeled IgR-3 Melanoma Cell 5 1 Line % total Incubation time Target cells (hr) alone C r release (range) PBL-target cell ratio 10 6 24 (b) 15 100 10 1 3 15 18 (9-12) (10-19) (11-20) (13-29) 22 31 37 46 (20-24) (26-^6) (32-50) (39-65) After c a r b o n y l iron a n d Ficoll-sodium m e t r i z o a t e . Mean values of six individual d o n o r s . the immune T-cell population may contain helper cells which are required for the differentiation of IgG antibody-forming cells and/or cells which produce macrophage activating factors.
Nat. Cancer Inst. 5 2 , 345 ( 1 9 7 4 ) . 15. R . B . C. Ting, H. T. H o l d e n , M. D. B o n n a r d and D. Lavrin, Effector mechanisms in t u m o r i m m u n i t y . Proc. 9th Int. Cancer Congress, edited b y P. Bucalossi, U. Veronesi and N. Cascinelli, Vol. 1, p . 2 5 8 . E x c e r p t a Medica, A m s t e r d a m , 1 9 7 5 . 16. R. Kiessling, E. Klein and H. Wigzell, " N a t u r a l " killer cells in the m o u s e . I. C y t o t o x i c cells with specificity for m o u s e Moloney leukemia cells.