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Download Clinical Management of Malignant Melanoma by John Peter Minton (auth.), John J. Costanzi (eds.) PDF

By John Peter Minton (auth.), John J. Costanzi (eds.)

Where do you start to appear for a contemporary, authoritative article at the prognosis or administration ofa specific malignancy? The few common onco­ logy textbooks are quite often outdated. unmarried papers in really expert journals are informative yet seldom entire; those are extra frequently prelimi­ nary stories on a truly constrained variety of sufferers. yes common journals usually put up stable indepth studies of melanoma subject matters, and released symposium lectures are frequently the easiest overviews to be had. regrettably, those studies and vitamins seem sporadically, and the reader can nev­ er make certain while an issue of certain curiosity can be lined. melanoma remedy and learn is a chain of authoritative volumes which goal to fulfill this desire. it really is an try to identify a severe mass of oncology literature protecting almost all oncology themes, revised usually to maintain the insurance brand new, simply on hand on a unmarried library shelf or through a unmarried own subscription. we have now approached the matter within the following type. First, via div­ iding the oncology literature into particular subdividions akin to lung melanoma, genitourinary melanoma, pediatric oncology, and so forth. moment, by means of asking eminent professionals in every one of those components to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor kind is roofed in a quantity showing usually and predictably, discussing present analysis, staging, markers, all types of therapy modalities, uncomplicated biology, and more.

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Extra resources for Clinical Management of Malignant Melanoma

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The likelihood of developing a melanoma in a particular site is different in men than in women, and the overall incidence is highest in Caucasians of Celtic origin [47, 48]. Caucasians have a seven-fold to fifteen-fold higher incidence of melanoma than Negroes living at the same latitude, and the factor said to account best for the observed differences in races is the solar-protective effects of melanin [3]. While primary cutaneous melanoma can, and does, invade nearly every organ of the body, the bulk of the cases tend to fall into four regions.

For primary melanomas arising on the forehead, preauricular region and anterior aspect of the ear, excision is carried out in-continuity with the superficial lobe of the parotid gland, containing the parotid nodes, infraparotid nodes, the submandibular bland and its adjacent nodes, as well as the superior and middle jugular nodes. For melanomas of the face, below the zygomatic arch, wide excision is effected in-continuity with the inferior pole of the parotid gland, the infraparotid, superior and middle jugular nodes, the submandibular gland and submandibular nodes as well as the submental nodes.

These four independent variables were variously combined to separate the patients into two risk groups. The high-risk patients had at least a 35 % or greater chance of developing visceral metastases within five years, while the low risk group had a greater than 85 % chance of being disease-free at five years. Criteria for the highrisk group were (a) mitoses 1/46/mm 2 in at least one area of the tumor, regardless of the primary tumor location; (b) a melanoma located at some site other than the forearm or leg and histologic evidence in the primary tumor of either ulceration 1/43 mm wide or microscopic satellites.

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