By Leonard S. Dreifus, Joel Morganroth (auth.), Leonard S. Dreifus, Albert N. Brest (eds.)
During the previous decade huge, immense development has been made within the improvement of recent cardiovascular medications and in our realizing of the medical pharma cology and the pharmacokinetics of outdated medicines. additionally, more moderen purposes of older brokers have emerged. for instance, vasodilators reminiscent of nitroglycerin are actually being hired within the therapy of congestive middle failure, and anti hypertensives reminiscent of bretylium are utilized in the administration of ventricular arrhythmias. person chapters during this publication specialize in (1) the scientific pharmacology and pharmacokinetics of the person medicines, and (2) the scientific functions of those medications, with cognizance additionally to serum concentrations, pathophysiology, and drug interactions the place applicable. The members to this article have worked to supply the reader with a significant, functional replace at the scientific makes use of and value of cardioactive medicinal drugs. we're deeply thankful to every of them for his or her beneficiant participation during this recreation. LEONARD S. DREIFUS, M.D. ALBERT N. BREST, M.D. 1. ANTIARRHYTHMIC brokers LEONARD S. DREIFUS and JOEL MORGANROTH preferably, the administration of cardiac arrhythmias has to be predicated on (1) whole elucidation of the genesis of some of the rhythm disturbances, and (2) a whole realizing of the pharmacologic motion of person antiarrhythmic brokers. purely with this distinctive details does it develop into attainable to manage a selected agent or brokers in particular powerful opposed to a given arrhythmia.
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Extra info for Clinical Applications of Cardiovascular Drugs
Podrin PJ, Lyakoshev A, Lown B, Mazur N: Ethmozin - a new antiarrhythmic agent. Circulation 57-58: 11-246, 1978. 118. Morganroth J, Orth DW, Dunkman WB, Pearlman AS, Horowitz LN, Josephson ME, Kastor JA: Comparative antiarrhythmic efficacy and tolerance of ethmozin and quinidine. Circulation 57-58: U-103. 1978. 119. Winkle RA, Meffin MJ. Fitzgerald JW. Harrison EC: Clinical efficacy and pharmacokinetics of a new orally effective antiarrhythmic, Tocainide. Circulation 54: 884, 1976. 120. Lalka D, Meyer MB, Duce BR, Elvin AT: Kinetics of the oral antiarrhythmic lidocaine cogenitor, Tocainide.
Caracta A, Damato AN: Procainamide. In: Drugs in cardiology, Donoso E (ed), New York, Stratton Intercontinental Medical Book Corporation, 1975, p I. 39. Schwartz ML, Covino BG: The antiarrhythmic activity of intraveneous procainamide. In: Procainamide hydrochloride. Princeton, New Jersey, Exerpta Medica, 1976, p 67. 40. Galeazzi R, Benet LZ, Sheiner LB: Relationship between the pharmacokinetics and pharmacodynamics of procain amide. Clin Pharmacol Ther 20: 278-289,1976. 41. Hoffman BF: The action of quinidine and procainamide on single fibers of dog ventricle and specialized conducting system.
The drug is contraindicated in the presence of glaucoma, preexisting second- or third-degree A V heart block, cardiogenic shock and congestive heart failure. Disopyramide can be used in conjunction with digitalis in the presence of supraventricular arrhythmias and with beta blocking agents, such as propranolol, in the presence of ventricular arrhythmias. 8. 1. Pharmacokinetics Ethmozin is the ethyl ester hydrochloride of 10 (3-morpho-linopropionyl phenothiazine-2-carbamic acid) which was synthesized at the Institute of Pharmacology and Chemistry of the Union of the Soviet Socialist Republic's Academy of Medical Science in 1964.