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Download Clinical Application of Radiolabelled Platelets by M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. PDF

By M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. Henningsen, J.-N. Petrovici (eds.)

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) have been the 1st to post a paper in regards to the in vivo thrombus detection with 111- In-labelled platelets. prior makes an attempt at scintigraphic thrombus localisation were disappointing end result of the unspecific binding of some of the isotopes used, in addition to the negative labelling potency or an inadequate low gamma-emitting estate. as a result of its actual features (2.8 days half-life, ninety four% gamma emission) 111 Indium grew to become out to be the simplest isotope for platelet kinetic reviews in addition to for the dimension of platelet incorporation by way of Thrombi for use up in the past. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets with out changing the functionality or the existence span of the platelets. This virtue has permit to a rise within the medical functions of 1211-In labelled platelets. this day, radiolabelled platelets are used for thrombus detection in different diversified scientific parts akin to cardiology, nephrology. angiology or neurology. even if many scientists and sanatorium medical professionals now mostly use radiolabelled platelet as a diagnostic instrument, there's as but now not a standardized labelling strategy. as well as this, there are neither standardized picture strategies for the various medical functions nor an contract approximately specificity and sensitivity of the strategy. In 1983, a symposium on Radiolabelled mobile Blood components was once prepared by way of M.Thakur, M.R.Hardeman and M.D.

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The procedure, being essentially the same as in use for bleeding time determination, is almost painless, however, small scars will remain visible for a while. , Hogg N. , Ware Herts Imperial Cancer Research Fund, London INTRODUCTION Indium-III labelled platelets introduced in the late 1970's as a new method of imaging thrombus have not gained widespread use and conventional radiographic techniques such as contrast phlebography for deep venous thrombosis remain as the favoured diagnostic approaches.

The rate of destruction is sometimes called destruction-pooling ratio (DIP). It might be more adequate to replace the DIP ratio by dtlda ratio in which dt is a function of time and da a function of the absolute increase of activity in one of both organs. One of the possible causes of increased liver uptake could be degree of damage to platelets, caused by the separation process. In our hands, microscopic checking and viability testing did not show any changes in platelet aspect or function. It is assumed that in patients with ITP two processes occur: lysis and phagocytosis.

Methods for separating platelets from blood and plasma. Haemorrh. 1975:33:648654 20. Hardeman MR. Cell Isolation Techniques: a critical review In: Thakur ML ed. New York, Plenum Publishing corporation 1985: 51-66 21. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962: 194. 927-929 22. O'Brien JR. Platelet aggregation. 19662:15:452-455 23. The effect of storage on adhesion and aggregation of platelets. 18:204-210 24. Murphy S, Gardner FH. Platelet storage at 22 o C: Metabolic morphologic and functional studies.

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