By Maurie Markman MD (auth.), Khalid Aziz MBBS, MRCP (UK), MRCP (IRE), FACG, George Y. Wu MD, PhD (eds.)
Despite significant advances within the analysis and remedy of melanoma, it is still an immense world wide killer, and its prevention continues to be the easiest approach to regulate. In melanoma Screening: a pragmatic consultant for Physicians, a panel of hugely skilled clinicians and researchers from worldwide describe screening ideas for a wide selection of cancers. The suggestions diversity from screening for breast, gynecological, and gastrointestinal cancers, to checking out for urogenital, dermatological, and respiration cancers. as well as offering the busy practitioner with easy accessibility to directions for specific cancers, the epidemiology and biology of some of the cancers, in addition to the sensitivity and specificity of the equipment, are mentioned intimately. A cross-cultural assessment of abdominal melanoma in Japan and esophageal melanoma in China finds using either high-tech diagnostic equipment, akin to chromoscopy and photofluorography, and occasional rate yet powerful tools, equivalent to balloon scraping. present and destiny purposes of molecular genetics, in addition to new radiological equipment in melanoma screening, also are mentioned in an authoritative and easy-to-read presentation.
melanoma Screening: a realistic consultant for Physicians bargains to all internists, oncologists, quite a few subspecialists, and first care physicians a concise functional evaluation of melanoma screening designed particularly for day-by-day use within the consulting room.
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Additional info for Cancer Screening: A Practical Guide for Physicians
1994) Localization of a breast cancer susceptibility gene, BRCA 2, to chromosome 13q12-13. Science 265:2088. 62. Easton D, Bishop D, Ford D, et al. (1993) Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am 1 Hum Genet 52:678. 63. Garber JE, Smith BL. (1996) Management of the high-risk and the concerned patient. In: Harris JR, Lippman ME, Morrow M, Hellman S, eds. Diseases of the Breast. Philadelphia: Lippincott-Raven, pp. 327,328. 64. Biesecker B, Boehnke M, Calzone K, et al.
T , ' ....... •-: Y''t : .. ......... _ . ~,. • . : . • .. -- Fig_ 2. (A) Normal squamous epithelium; (B) low-grade dyplasia (CIN 1). adjunct diagnostic tool that occasionally helps in the management of equivocal lesions. Cervicography Cervicography is a photographic screening technique in which a 35-mm photo is taken of the cervix after staining with acetic acid. Studies have found cervicography to be more sensitive but significantly less specific than cytologic screening. MANAGEMENT OF THE ABNORMAL PAP SMEAR A patient with an abnormal Pap smear should be referred to a trained gynecologist or a physician trained in the use of colposcopy.
SCREENING METHODS The most important step in screening may be to obtain an accurate, detailed family history encompassing both maternal and paternal relatives and extending back at least three generations. It is important to get a sense of the number of female relatives, because in small families, a genetic inheritance pattern may not be as obvious as in large families. Patients should be specifically queried about ovarian, breast, uterine, and colon cancers, including breast and colon cancers in both male and female relatives.