By Paolo Aloisi M.D., Francesco Martella Ph.D. (auth.), Mauro Bologna (eds.)
Biotargets of melanoma in present medical Practice provides an up to date and reasoned evaluation of the present prestige of information about the significant melanoma varieties with a distinct specialise in the present biomarkers, genes concerned and the capability destiny pursuits of cutting edge treatments. the quantity contains for every significant melanoma variety, a finished even if concise dialogue of epidemiology, affirmed and leading edge biomarkers for prognosis, and outlines of the correct genes for analysis and (individualized) remedy via biotarget-specific new molecular remedies, with the most recent info at the validation prestige of every novel biomarker. person chapters are devoted to the key melanoma kinds, plus a different bankruptcy on metastasis. the current debate on patentability of genetic info utilized to diagnostics and therapeutics of melanoma is usually discussed.
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Extra info for Biotargets of Cancer in Current Clinical Practice
In some countries, such as the USA, recent data indicate that the incidence of oral cavity cancer is stable and may even be in slow decline . This may, in part, parallel the reduction in lung cancer as smoking rates have dropped . Other populations, such as Japan and the UK, do not mirror such changes and report increases in incidence and/or mortality [5, 6]. In the USA, there appears to be a slow and steady increase in overall survival [7, 8]. Recent Changes of Note A rise in the number of patients younger than 40 years has been reported over the past two to three decades [9–12].
Li Y, Guessous F, Kwon S, et al. PTEN has tumorpromoting properties in the setting of gain-of function p53 mutations. Cancer Res. 2008;68(6):1723–31. 46. Smith JS, Tachibana I, Passe SM, Huntley BK, Borell TJ, Iturria N, O’Fallon JR, Schaefer PL, Scheithauer BW, James CD, Buckner JC, Jenkins RB. PTEN mutation, EGFR ampliﬁcation, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst. 2001;93(16): 1246–56. 17 47. Ang C, Guiot MC, Ramanakumar AV, Roberge D, Kavan P.
Malignant Salivary Gland Tumours (ICD10 C07–08) Malignant tumours of the salivary glands are rare, comprising approximately 4–6% of all head and neck tumours . The most recent WHO classiﬁcation identiﬁes 20 distinct histological sub-types, and, despite this, a signiﬁcant number of tumours are still not easily classiﬁed . The most recent SEER data demonstrate a small but signiﬁcant increase in overall incidence of salivary gland carcinoma in the USA over the period 1975–2007 . Much of the data on the relative incidence of sub-types come from large case series.