By Osias Stutman (auth.), Ronald B. Herberman (eds.)
Where do you start to appear for a up to date, authoritative article at the prognosis or administration of a selected malignancy? The few normal onco logy textbooks are regularly outdated. unmarried papers in really expert journals are informative yet seldom entire; those are extra frequently prelimi nary stories on a really constrained variety of sufferers. definite basic journals often submit sturdy indepth studies of melanoma subject matters, and released symposium lectures are frequently the easiest overviews on hand. regrettably, those experiences and supplementations seem sporadically, and the reader can by no means verify whilst a subject matter of certain curiosity might be lined. melanoma remedy and study is a sequence of authoritative volumes which target to satisfy this want. it's an try and determine a serious mass of oncology literature masking almost all oncology issues, revised often to maintain the assurance modern, simply on hand on a unmarried library shelf or by way of a unmarried own subscription. we've got approached the matter within the following type. First, by means of divid ing the oncology literature into particular subdivisions akin to lung melanoma, genitourinary melanoma, pediatric oncology, and so forth. moment, through asking eminent professionals in each one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor style is roofed in a quantity showing usually and predictably, discussing present prognosis, staging, markers, all kinds of remedy modalities, uncomplicated biology, and more.
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Extra resources for Basic and Clinical Tumor Immunology
21J for extensive review). In addition, the present day enthusiasm about NK cells and their possible role in IS, has generated those same poorly planned experiments using beige mice, as those we criticized in the past using neonatally thymectomized animals : probably as part of the wave of beige mouse studies predicted by Mitchison in 1980 . 2). 2). As a matter of fact, the phenomenon of' cryptomnesia' in science, so well described by Merton [88J - which in essence is the rediscovery of known facts as if they were new findings, in its 'positive' formulation - has acquired a 'negative' aspect in the IS studies, which is the forgetting or overlooking of already known facts which do not agree with the bias towards expected results (for some examples within the conventional IS studies see our refs.
The results show that papilloma development in SEN CAR skin seemed to be unaffected by the immune status of the host; and more importantly that the papilloma incidence in intact nudes, nude grafts or the adjacent skin in the grafted nudes, were quite comparable and that such incidence, albeit much lower than in the SENCAR mouse, was quite comparable to the incidence in BALB/c skin, which belongs to the strains that are poorly sensitive to this type of carcinogenesis . 50 or more papillomas .
As it was indicated by the authors, this susceptibility of the nude mice to skin carcinogenesis by systemic ENU may be explained by other reasons besides the lack of conventional IS . In our own studies on transplacental carcinogenesis with ENU in nude mice partially inbred in the CBA/H background , we did not detect any skin tumors in nudes or controls, using a similar dose of ENU as in Anderson et a1. . However, we treated the pregnant mothers on day 16-17 of gestation, while the Anderson et a1.