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Download Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is essential to homeostasis within the breathing tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial ailments, together with bronchial asthma, persistent bronchitis and cystic fibrosis. This quantity offers huge ranging and in-depth assurance of the clinical and medical elements of airway mucus. It commences with introductory chapters which deal with the biochemical and molecular organic foundation of airway mucus and keeps with complete assurance of a few of the physiological and rheological elements of respiration secretions. The scientific features of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory ailments of the airway. the quantity concludes with a dialogue of the healing features of the subject, either when it comes to the prospective ways to the therapy of mucus hypersecretion and the interplay of those medicines with airway mucus. Written via major specialists within the box, every one contribution presents a complete evaluate of its specific topic. Reflecting the newest advances during this vital sector of respiration learn, this quantity should be of significant curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Additional resources for Airway Mucus: Basic Mechanisms and Clinical Perspectives

Sample text

Am J Respir Cell Mol Bioi 12: 196-204. 72. Reddy MS, Scannapieco FA, Levine MJ (1988) Tracheobronchial mucin: Interactions with nontypeable Haemophilus injluenzae. Am Rev Resp Dis 137: A317. 73. Davies JR, Carlstedt I, Nilsson A-K, Hrekansson A, Sabharwal H, Van Alpen L, Van Ham M, Svanborg C (1995) Binding of Haemophilus injluenzae to purified mucins from the human respiratory tract. Infoct Immun 63: 2485 - 2492. 74. Kubiet M, Ramphal R (1995) Adhesion of nontypeable Haemophilus injluenzae from blood and sputum to human tracheobronchial mucins and lactoferrin.

These studies also show that the so-called neutral PAS-rich mucins, in the nomenclature of the histologist, are in fact negatively charged molecules. It is evident from mRNA expression and histological studies that respiratory secretions contain a mixture of mucin gene products and that the different apoproteins may exist in a number of glycoforms. In our most recent investigations, we have analysed respiratory secretions in order to assign a genetic identity to each of the gel-forming, oligomeric mucin species present and determine whether they are present as different glycoforms.

56. Jeffiy PK, Reid LM (1977) The respiratory mucus membrane. In: Brain JD, Proctor DF, Reid LM eds. Respiratory defence mechanisms. New York: Marcel Dekker, 193 -245. 57. Lopez Vidriero MT, Reid LM (1978) Bronchial mucus in health and disease. Med Bull 34: 63-74. 58. Spicer SS, Schulte BA, Charkin LW (1983) Ultrastructural and histochemical observations of respiratory epithelium and gland. Exp Lung Res 4: 137-156. 59. Mazzuca M, Lhermitte M, Lafitte J-J, Roussel P (1982) Use of lectins for detection of glycoconjugates in the glandular cells of human bronchial mucosa.

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