By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)
A complete evaluate of the hot advancements in DNA fix learn that experience power for translational purposes. The e-book explains intimately many of the organic mechanisms wherein melanoma cells can avert anticancer remedy and boundaries its usefulness in sufferers. in addition they overview the impression of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of different DNA fix enzymes corresponding to PARP and DNA-PK. The booklet captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many intriguing new makes use of of DNA fix inhibitors, both on my own or together with anticancer therapies.
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Additional info for Advances in DNA Repair in Cancer Therapy
31 The phosphorylation occurs on an S/T-Q motif, although some serine/threonine in other sequences/targets could be phosphorylated [59, 104]. The phosphorylation of Artemis may help to activate its endonuclease activity [60, 105]. However, although DNA-PK also phosphorylates Ku, XRCC4, and Cer-XLF in the cell, mutational studies concluded that these phosphorylations are not functionally important, at least for NHEJ . Thus, like ATM, DNA-PK may phosphorylate unknown substrates in vivo involved in processes other than DNA repair [106, 107].
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