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Download Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, PDF

By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A complete evaluate of the hot advancements in DNA fix learn that experience power for translational purposes. The e-book explains intimately many of the organic mechanisms wherein melanoma cells can avert anticancer remedy and boundaries its usefulness in sufferers. in addition they overview the impression of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of different DNA fix enzymes corresponding to PARP and DNA-PK. The booklet captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many intriguing new makes use of of DNA fix inhibitors, both on my own or together with anticancer therapies.​

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31 The phosphorylation occurs on an S/T-Q motif, although some serine/threonine in other sequences/targets could be phosphorylated [59, 104]. The phosphorylation of Artemis may help to activate its endonuclease activity [60, 105]. However, although DNA-PK also phosphorylates Ku, XRCC4, and Cer-XLF in the cell, mutational studies concluded that these phosphorylations are not functionally important, at least for NHEJ [59]. Thus, like ATM, DNA-PK may phosphorylate unknown substrates in vivo involved in processes other than DNA repair [106, 107].

J Mol Biol 335(2):573–582 101. Rivera-Calzada A, Spagnolo L, Pearl LH et al (2007) Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. EMBO Rep 8(1):56–62 102. DeFazio LG, Stansel RM, Griffith JD et al (2002) Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J 21(12):3192–3200 103. Hammarsten O, Chu G (1998) DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc Natl Acad Sci U S A 95(2):525–530 104. Lees-Miller SP, Sakaguchi K, Ullrich SJ et al (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

Drouet J, Delteil C, Lefrancois J et al (2005) DNA-dependent protein kinase and XRCC4DNA ligase IV mobilization in the cell in response to DNA double strand breaks. J Biol Chem 280(8):7060–7069 57. Drouet J, Frit P, Delteil C et al (2006) Interplay between Ku, Artemis, and the DNA dependent protein kinase catalytic subunit at DNA ends. J Biol Chem 281(38):27784–27793 58. Wu PY, Frit P, Malivert L et al (2007) Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

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