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By D. de Moulin

The 3rd Breast melanoma operating convention of the Breast melanoma Cooperative crew of the eu association for learn on therapy of melanoma, to be held in Amsterdam on April 27-29, 1983, used to be the main cause for penning this booklet. It was once feh brief assessment of the most pathogenetic conceptions and healing ideas that have offered themselves in regards to mammary melanoma during Western background , can help to attract a extra entire photo of the place we stand at the present time. it's not effortless to make your mind up which principles, even if discarded, deserve but to be remembered and which authors from the prior could be thought of to be actually consultant of the medical weather in their age. Twenty centuries have produced an excessive amount of rules and the variety of clinical authors who complex, or rejected, or transformed, or revived them, is admittedly uncountable. So the historian has to make a selec­ tion and offerings are perforce subjective and open to feedback. In scripting this booklet i attempted to refer to unique resources within the unique language up to attainable. those resources weren't regularly strictly clinical given that I aimed toward putting the matter of malignant breast disorder - which would function a paradigm of melanoma usually - in a a bit of wider context. For the background of medication isn't just a heritage of rules, but in addition that of individuals, of associations, of society.

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Townsend, one of his parishioners in Stratford-on-Avon: 72 First they cutt the skin cross and laid itt back, then they workt their hands in ytt, one above and the other below, and so till their hands mett, and so brought itt out. They had their needles and waxt thread ready, but never ust them; and allso their cauterizing irons, but they used them not: she lost not above six ounces of blood in all. Dr. Needham coming too late, staid next day to see it opened. Hee said itt was a melliceris (a cystic tumour filled with a honey-like substance), and not a perfect cancer; but itt would have been one quickly.

Petrus Camper, for instance, first thought that cancerous poison spread from the diseased breast along musdes and nerves. After his discovery of the 'mossy glands', as he called them, alongside the intern al mammary blood vessels, which he associated with the only too common experience of local recurrence, he was converted to the lymphogenous theory of transmission llO (Fig. 16). 38 Fig. 15. Pectorallymph drainage according to Mascagni. The concept of 'metastasis' still seems to have been somewhat alien to GiovanniBattista Morgagni (1682-1771), the great eighteenth-century pathologist.

109 The word 'cell' is not yet used in the sense of tissue-cell, however. It was employed to describe the macroscopic aspect of body fat. Camper in 1797 did look upon cancer as 'a wholly changed and destructed glandular mass', but it is not quite clear whether he discarded the influence of humours in its origin. 110 Menopause and all kinds of psychic influences are almost invariably cited in the medicalliterature of the eighteenth century as additional factors that might encourage the development of scirrhus of carcinoma.

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